《Table 3Pharmacokinetic parameters of normal rats singly intragastric administrated with salidroside
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《Salidroside shows a particular pharmacokinetic property in model rats of myocardial ischemia》
The sensitive method we developed was successfully used for the determination of the pharmacokinetic properties of SD rats treated with salidroside.After orally administration of salidroside(20,50,and 100 mg/kg)in normal rats,salidroside was rapidly absorbed because of a mean Tmaxwas about 40 min and Cmaxvalues was about(4.5±1.48),(11.18±2.52) ,and(13.59±4.65)μg/m L,which are listed in Table 3.The mean drug concentration–time curves of salidroside,linearity of AUC0~∞–dosage are shown in Fig.5,and the regression equation is:y=0.3319 x+1981.5.
图表编号 | XD007994600 严禁用于非法目的 |
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绘制时间 | 2018.04.18 |
作者 | Hui-lin Gu、Run-bin Sun、Fei Fei、Li-xiang A、Hao-xue Gao、Ming-xue Tao、Si-qi Feng、Na Yang、Yue Zhang、Ji-ye Aa、Guang-ji Wang |
绘制单位 | Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, State Key Laboratory of Natural Medicines, China Pharmaceutical University、Jiangsu Province Key Laboratory of Drug Metabolism |
更多格式 | 高清、无水印(增值服务) |
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