《Table 7–Pharmacokinetic parameters of Lop after topical application of Fc and Fop in rats (n=3) .》下

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《"Systematically optimized topical delivery system for Loperamide hydrochloride: Formulation design,in vitro and in vivo biopharmaceutical evaluation"》

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Fig.2 also showed the distribution of Lop skin retention（epidermis/dermis）of the hairless mice.Delivery of Lop in the skin layers by optimum gel Fop was found to be significantly greater than Fc.Table 6 gives the numeric values of dermatokinetic parameters AUC，Cskin max and Tskin max.The maximum concentration achieved in skin（Cskin max）for Fop and Fc was 22.44±3.81 mg/g and 16.56±1.88 mg/g，respectively.Moreover，AUC of Lop in skin for Fop was also found to be higher than Fc.The results，therefore，confirmed that Lop in Fop travelling as far as the deeper skin layer and forming deposition within the skin.The main challenge for topical delivery system is to penetrate across through the SC barrier and target the active drug into injury sites as much as possible.Thus，the transport characteristics of Fop showed the expected results.