《Table 1 Plasma concentrations of VPA in control and CSE rats after gastric administration of VPA》

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《Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus》

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VPA:Sodium valproate；CSE:convulsive status epilepticus.Data are expressed as the mean±SEM.

As shown in Table 1，normal rats exhibited effective VPA levels（64.98±10.69μg/mL and 96.91±20.36μg/mL）when treated with 300 mg/kg or 400 mg/kg of VPA，respectively.CSE rats treated with 300 mg/kg of VPA also demonstrated an effective VPA level（82.26±11.23μg/mL）.Thus，we selected the 300 mg/kg VPA treatment paradigm to treat the CSE rats in subsequent experiments.