《Table 3.Plasma Opg and Rankl concentrations in wild-type (Lgals3+/+) , heterozygous (Lgals3KO/+) ,

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《Enhanced cortical bone expansion in Lgals3-deficient mice during aging》

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Opg，osteoprotegerin；Rankl，receptor activator of nuclear kappa B ligand.aValues are expressed as mean±S.E.M.（n=6–10）；Holm–Sidak post-hoc analysis adjusted P-values compared to wild type；bold values highlight*P<0.05，**P<0.01.

To determine if galectin-3 plays a role in trabecular bone mass，we measured trabecular bone parameters in the distal femur and L3vertebral body by microcomputed tomography（μCT）.The results for femurs and L3 vertebrae are displayed in Supplementary Tables 2 and 3，respectively.While Lgals3KO/KOfemale mice had normal trabecular bone measurements in femurs and L3 vertebrae at 12 wk，by 36 wk they had significantly elevated bone mineral density（BMD）and bone volume fraction（BV/TV）in both the femur（+13.3%and+114.8%，respectively；Fig.1）and the L3 vertebral body（+16.7%and+34.7%，respectively）.At 36 wk，the increased BV/TV in Lgals3KO/KOfemurs was due to significant contributions from increased trabecular thickness（Tb.Th；+14.5%）and trabecular number（Tb.N；+75%），as well as a significant decrease in trabecular spacing（Tb.Sp；-9.5%）.The increase in BV/TV in the vertebral body was primarily due to a significant increase in Tb.Th（+12.8%）.