《Table 3 The concentration of plasma AAs of EAU and control group》

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《Metabolic profile analysis of free amino acids in experimental autoimmune uveoretinitis rat plasma》

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AA:Amino acid；EAU:Experimental autoimmune uveoretinitis.↓:AAs descended more than 10%compared to control group；↑:AAs increased more than 10%；-:The change of AAs no more than 10%.Compared with control group，aP<0.05.

In this study，we found that plasma AAs was significant difference between EAU and control group.There were 9 kinds of AAs in EAU rats whose concentrations were lower than in control group，5 kinds of AAs were higher in EAU（Figure 3，Table 3）.Notably among these AAs，Tyr，Gly，Met，His，Ala，Glu，Try，Pro and Asp were decereased，while the levels of Leu，Thr，Val，Iso and Cys were increased.The most decreased AA was Tyr，which is the essential AA，and related to Tyr with dopa，dopamine，norepinephrine and epinephrine，and also the product of metabolism of phenylalanine.In this study，the content of Phe was hardly changed.In contrast，the most increased AA was Leu，demonstrating that signal transduction pathways related to Leu may contribute to interpretation of cellular signals[34].Moreover，AAs can also influence protein by regulating protein synthesis and degradation.Because of Tyr，Leu，Gly and Met represent a biologic molecules exerting dynamic，highly disparate physiologic processes in EAU.Thus，we have applied an analytical tools to understand of AA in EAU.