《Table 3–The main pharmacokinetic parameters of CTN after oral administration of the optimized CTN-S

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《Development of cryptotanshinone-loaded pellets for angina chronotherapy:In vitro/in vivo prediction and evaluation》

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Pharmacokinetics in rats was investigated to verify whether the CTN-SRPs optimized based on deconvolution had a desirable plasma drug concentration-time profile.As shown in Fig.3，the plasma concentration-time curve of CTN-SRPs was similar with the simulated mean predicted one.The percent prediction error（%PE）value of CTN plasma concentration at each time point was calculated according to equation%PE=（observed value-predicted value）/observed value×100%[26].The%PE values from 4 to 16 h were smaller than 15%and the%PE values from 8 to 12 h were smaller than10%.These%PE values demonstrated that the actual observed plasma concentration values were very close to the predicted concentration data calculated and simulated according to the incidence of variant angina during 24 h.These results further indicated that the optimized CTN sustained-release formulation succeeded in achieving highest blood concentrations for maximal protection during the time period when angina pectoris is of greatest risk and occurrence.In addition，the pharmacokinetic parameters（C max，T max，MRT，AUC 0–t and AUC 0–∞）of the optimized CTN-SRPs were calculated and compared with the predicted values in Table 3.These almost equivalent values further validate that the in vivo performance of these CTN-SRPs after oral administration was in accordance with the expected one.