《Table 3–Pharmacokinetic parameters of CsA following oral administration of SNEs.》

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《Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery》

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The compositions of SNEs are listed in supplementary Table S1.Short（SCT）and long（LCT）chain triglycerides，as oil phase，were widely used to prepare different SNE formulations.Ethanol and 1，2-propanediol increase the solubility of CSA.Cremophor EL has good capacity for self-emulsify.The SNEs are further synthesized according to Fig.1.The particles size，polydispersity index and zeta potential of different SNEs are shown in Table 1.The samples had an average particle size of approximately 106.0 nm，and no significant change in particle size was found with F127 modification.The zeta potentials of SCT-SNE and LCT-SNE were approximately-20.0 mV；however，F127 modification increased zeta potential to 1.0 mV and-7.4 mV，respectively.The increased of zeta potential indicated that the extension of the hydrophilic polyethylene oxide（PEO）chains coated the oil phase surface，which had increased the hydrophilicity of SNEs and shielding of surface charges.