《Table 1–The pharmacokinetic parameters of TMP in joint tissue and synovial fluid after intra-articu

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《Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis》

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The pharmacokinetic parameters of TMP in joint tissue and synovial fluid were listed in Table 1.The area under the curve（AUC）of freeze-dried microspheres in the joint tissue was extremely large，13.2 times that of the TMP solution and 7.9 times that of the vacuum-dried microspheres.The AUC of the freezedried microspheres in synovial fluid were 17.6 and 11.6 times larger than that of TMP solution and vacuum-dried microspheres，respectively.The mean residence time（MRT）of freeze-dried microspheres in joint tissue was 9.2 times longer than that of TMP solution and 4.6 times longer than that of vacuum-dried microspheres.Thus，freeze-dried microspheres not only exhibited localized high concentrations in joint tissue，but also displayed a long retention time for one month.