《Table 6 Influences of the pilot product of QFJBT on hematological parameters of rats in a 3-month,

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Notes:data are presented as the mean±SD（n=11～12）.Abbreviation:RBC represents erythrocyte count；WBC represents white blood cell count；HGB represents hemoglobin concentration；HCT represents hematocrit；LYM represents lymphocyte count；LY represents total a

In the chronic oral toxicity studies，about 67%animals treated with QFJBT at the dose of 9.72 g/kg（equivalent to 100-fold clinical dosage）showed mild or moderate decrease of activity and diarrhea in the initial stage of the experiment（7～14 d after the initiation of QFJBT treatment）.The results of laboratory investigation showed that all hematological parameters（erythrocyte，leukocyte and platelet counts，hemoglobin concentration，hematocrit，lymphocyte and differential lymphocyte counts）（Table 6） and bloodbiochemicalparameters（aspartate aminotransferase，alanine aminotransferase，alkaline phosphatase，total protein，albumin，total bilirubin，glucose，creatinine，triglycerides）（Table 7） of QFJBT-treated rats fell within the range of normal biological variation as compared with vehicle-treated rats.No mortality or specific toxic responses or treatment-induced pathological changes in all test organs and tissues were observed in animals after 3months of repeated dosing with QFJBT.