《Table 3.Leukogram after Repeated i.p.Injections of TAA and CCl4 to Rats, Compared to that of Normal

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《Hepcidin-orchestrated Hemogram and Iron Homeostatic Patterns in Two Models of Subchronic Hepatic injury》

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Note.*Mean significantly（P<0.05）different from it.WBC:white blood cell；Lymph:lymphocytes；Mid-sized:mid-sized cells；Gran:granulocytes；TAA:10 mg/100 g rat weight dissolved in isosaline；CCl4:100μL/100 g rat weight diluted as 1:4 in corn oil.Mean±SE，n=9 f

The establishment of liver fibrosis in both models was confirmed by elevation of liver transaminases（AST and ALT）that leaked to blood from the injured hepatocytes upon repeated administrations of either of hepatotoxins（Table 1）.The values of both transaminases were markedly higher in the TAA model than those in the CCL4model.This finding indicates the higher capability of TAA as a fibrosis inducer compared with CCL4，despite applying standardized doses of each hepatotoxin.