《Table 3 Criteria including tumor biomarkers》

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《Hepatocellular carcinoma-time to take the ticket》

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AFP:Alpha-fetoprotein；CT:Computed tomography；DCP:Des-gamma carboxy prothrombin；PET:Positron emission tomography；TTV:Total tumor volume.

Ultimately，all of these protocols and criteria were created because we do not have a complete understanding of the genetic alterations that lead to carcinogenesis and the way that different mutations affect cancer biology.In the future，having a better understanding of the genetic makeup of tumors and using new markers，such as long noncoding RNAs[26]，can make these criteria obsolete.Until then，we can strive toachieve the best result possible without causing harm to other patients.