《Table 1 Identification of plasma biomarkers in HCMV hepatitis cases》

《Table 1 Identification of plasma biomarkers in HCMV hepatitis cases》   提示:宽带有限、当前游客访问压缩模式
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《基于UHPLC-MS的代谢组学技术研究婴儿巨细胞病毒肝炎湿热内蕴证(英文)》


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Note:aVariable importance in projection(VIP)values were obtained from OPLS-DA models with a threshold of 1;bContent variance compared to normal group.Levels of potential biomarkers were labeled with(↓)down-regulated and(↑)up-regulated.

For plasma samples,664and 412compounds were detected in the positive ion mode for the upper and lower phases.Both unsupervised PCA scores plot(Figure 1A,Figure2A)and supervised OPLS-DA scores plot(Figure 1B,Figure 2B)showed significant differences in the metabolomic profiles between the patients and NCs,demonstrating that the metabolites in plasma were altered by HCMV hepatitis.The R2 Y values for the OPLS-DA model were 0.980for the upper phase and 0.950for the lower phase.Q2 values were 0.869for the upper phase and 0.898for the lower phase.Finally,22differential biomarkers were identified in the plasma samples(Table 1).