《Table 1 EBV proteins and their effects on MS clinical/MRI outcomes》

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《The role of Epstein-Barr virus in multiple sclerosis:from molecular pathophysiology to in vivo imaging》

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EBV:Epstein-Barr virus；MS:multiple sclerosis；CIS:clinically isolated syndrome；RRMS:relapsing-remitting multiple sclerosis；PPMS:primary progressive multiple sclerosis；EBNA:EBV nuclear antigen；VCA:viral capsid antigen；LMP:latent membrane protein；EA:early an

The initial report of association between infectious mononucleosis occurrence and the subsequent development of MS have been corroborated by multiple meta-analysis（Martyn et al.，1993；Thacker et al.，2006；Handel et al.，2010）.Interestingly，the prevalence of both infectious mononucleosis and MS demonstrates a co-localizing and uneven geographical distribution that may be explained by the hygiene hypothesis（Ascherio et al.，2012）.According to the hygiene hypothesis，the relative lack of early exposure to common pathogens during childhood in areas of with high levels of sanitation and hygiene may increase the risk for aberrant immune responses and autoimmune diseases if they are exposed to infectious triggers such as EBV later during adolescence and adulthood（Table 1）（Ascherio and Munger，2007） .