《Table 4.The IC50 values of IMB-XH1 for MBLs.》

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《IMB-XH1作为新型新德里金属-β-内酰胺酶-1(NDM-1)抑制剂的研究（英文）》

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The MIC ofβ-lactam antibiotics combined with IMB-XH1 at different concentrations against the engineered expression bacteria containing blaNDM were tested.We also confirmed that NDM-1 can hydrolyze variousβ-lactam antibiotics.The results showed that the MIC of ampicillin，ticarcillin and meropenem in combination of 20μg/mL IMB-XH1 were reduced by>8 times，4 times and 8 times，respectively（Table 3）.To further identify the inhibition model，the inhibition constants Ki of IMB-XH1 against NDM-1 were determined.According to the results obtained by Lineweavere-Burk plot，IMB-XH1 appeared to be a noncompetitive inhibitor of NDM-1（Fig.5）and did not affect the active site of NDM-1 through competitive binding.