《Table 1 Effect of acupuncture on autophagy in cerebral ischemia and reperfusion》

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《Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury》

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:Up-regulation of protein expression；:down-regulation of protein expression.GV20:Baihui；GV24:Shenting；GV4:Mingmen；GV26:Shuigou；LI11:Quchi；ST36:Zusanli；EA:electroacupuncture；LC3:microtubule associated protein-1 light chain 3；mTOR:mammalian target of rapamy

As a crucial pathological change in cerebral ischemia/reperfusion injury，autophagy plays a double-edged role.During the first few hours of reperfusion，autophagy helps maintain cell survival through clearing damaged organelles.However excessive autophagy at later stages leads to autophagic cel death（Yan et al.，2011；Gao et al.，2012；Xia et al.，2013）Therefore，autophagy may be a potential therapeutic target for ischemic cerebrovascular diseases.EA，an important alternative therapy，can effectively reduce the risk of recurring ischemic cerebrovascular disease and disability.In recent years，results from animal experiments have demonstrated that EA exerts an influence on the whole process of autophagic flux by regulating the expression of autophagy-related markers such as the ULK1 complex，Beclin1，LC3 and p62.Other studies have indicated that EA treatment might regulate autophagy via the PI3K-AKT-mTOR signaling pathway，thereby playing a neuroprotective role in cerebra ischemia/reperfusion injury（Table 1）.