《Table 2Hepatoprotective effect of TOPE on hematological parameters in RIF-INH-induced hepatotoxicit

  提示：宽带有限、当前游客访问压缩模式

本系列图表出处文件名：随高清版一同展现

《Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicinisoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress》

1. 获取 高清版本忘记账户？点击这里登录

1. 下载图表忘记账户？点击这里登录

Group 1:negative control，receiving 10 mL/kg body weight（b.w.）distilled water；Group 2:disease control group，receiving RIF+INH（both 100 mg/kg b.w.，the same below）+10 mL/kg distilled water；Group 3:receiving RIF-INH+TOPE（125 mg/kg b.w.）；Group 4:receiv

The effects of TOPE（125–500 mg/kg）on serum enzymes，proteins and bilirubin in RIF-INH-intoxicated rats are shown in Table 3.Statistically significant hepatotoxicity was induced in rats following intoxication with RIF-INH.The percentage elevation of hepatotoxicity in disease control group was AST（25%），ALT（18%），ALP（32%），CBIL（28%）and TBIL（26%），and depression of TP（31%）and ALB（32%）.TOPE or silymarin markedly（P<0.001）decreased the elevated AST，ALT，ALP and TBIL levels in RIF-INH intoxication rats，and elevated the depressed levels of TP，ALB and CBIL.The percentage hepatoprotection of Groups 3，4，5，6 and 7，compared to the RIF-INH control group，was as follows:AST（180%，191%，215%，196%and 213%），ALT（246%，479%，521%，491%and 474%），ALP（163%，154%，192%，194%，and 236%），TP（77%，62%，52%，52%and92%），ALB（77%，88%，100%，80%and 82%），CBIL（210%，249%，276%，305%and 70%）and TBIL（251%，258%，266%，242%，and240%）（Table 3） .