《Table 4Effects of TOPE on lipid profile and renal function in RIF-INH-induced hepatotoxicity in Wis

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《Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicinisoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress》

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Group 1:negative control，receiving 10 ml/kg body weight（b.w.）distilled water；Group 2:disease control group，receiving RIF+INH（both 100 mg/kg b.w.，the same below）+10 mL/kg distilled water；Group 3:receiving RIF-INH+TOPE（125 mg/kg b.w.）；Group 4:receiv

The effects of experimental treatments on body weights are presented in Table 1.The treatments produce significant alterations in the weights（P<0.0001）.The study found that statisticallysignificant differences in body weight were present between all treated groups and the disease control group.TOPE（125–500 mg/kg），the reference drug silymarin（50 mg/kg）and100 mg/kg RIF+100 mg/kg INH demonstrated a minimal marked effect on weights of experimental animals（Table 1）.At the 8th week，animals in Group 3，receiving TOPE 125 mg/kg，had significantly elevated body weights compared to their initial body weights.The reference drug（Group 6）and the middle dose of TOPE（250 mg/kg；Group 7）significantly（P<0.05 and P<0.01，respectively）increased body weights from the first week to the eighth week compared to the initial.Treatment with RIF-INH produced a marked reduction in liver weights compared to the negative control.Significant（P<0.001）increase in liver weight occurred in rats given TOPE 250 mg/kg plus RIF-INH 100 mg/kg compared to the disease control group（Table 1）.Other experimental doses，the reference and normal control did not exhibit any marked effect on liver weights.