《Table 3Randomized clinical trials evaluating optimal DAPT duration for East Asian patients with cor

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《2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI》

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aBARC，bleeding academic research consortium；BES，biolimus-eluting stent；CI，confidence interval；DAPT，dual antiplatelet therapy；DES，drug-eluting stent；DES-LATE，Optimal Duration of Clopidogrel Therapy With DES to Reduce Late Coronary Arterial Thrombotic

Because the benefit/risk ratio with prolonged DAPT can be different between East Asian and Caucasian populations following PCI，the optimal duration of DAPT might be reconsidered based on the data of East Asian patients.Currently，six large-scale randomized clinical trials are available from East Asian patients treated with DES（Table 3）.Overall，prolonged DAPT use（12–24 months）decreased numerically the prevalence of ischemic events with a numerical increase of serious bleeding episodes than short-term DAPT use（3–12 months）[107–112].However，net（ischemic+bleeding）events appeared neutral across the treatments.Four clinical trials evaluated the clinical efficacy and safety of 3–6 month DAPT compared with 12-month DAPT after newergeneration DES implantation[109–112].These trials did not show any significant differences of major ischemic and bleeding events between 12-month vs.short-term DAPT strategy.Even in ACS patients，the benefit of 12-month DAPT as compared with 3–6 month DAPT was not definite.Another a real-world study showed that PCI-treated patients insisted on 6–12 month DAPT treatment had a lower adverse cardiac event rate（cardiovascular death，MI and revascularization）than those with a short-term DAPT treatment（HR，0.172；95%CI，0.039 to 0.763；P=0.021）[113].