《Table 2The cutoffs of HPR in East Asian patients evaluated by the receiver-operating characteristic

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《2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI》

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aACCEL-LOADING-ACS，ACCELerated Inhibition of Platelet Aggregation，Inflammation and Myonecrosis by Adjunctive Cilostazol LOADING in Patients With Acute Coronary Syndrome；ACS，acute coronary syndrome；AMI，acute myocardial infarction；CAD，coronary artery di

In addition to the analysis from randomized clinical trials，several registries have suggested the controversial results in clinical efficacy and safety of ticagrelor for East Asian patients with ACS（Table 1）.In the KAMIR-NIH registry[21]（the Korean prospective observational cohort；n=9355），no significant difference in ischemic events at 12 months was observed between the ticagrelor vs.clopidogrel group（2.1%vs.2.1%，P=0.447）after propensity score matching（572 pairs）.However，the incidence of BARC major bleeding（type 2，3 or 5）was higher in ticagrelor than in clopidogrel（8.0%vs.3.1%，P<0.001）.Taiwan Health Insurance Research Database[22]（27，339 AMI patients）was retrospectively analyzed and showed the different result:the ischemic event rate was 22%lower in the ticagrelor group than in the clopidogrel group（10.6%vs.16.2%；HR，0.779；95%CI:0.684 to 0.887）with the similar risk of major bleeding between the groups（3.2%vs.4.1%；HR，0.731；95%CI:0.522 to 1.026）.There would be concerns regarding reliability in terms with the quality of the registry data.