《Table 2Frequency of the top 10 shared neoantigens predicted by recurrent mutations in combination w

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《TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis》

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Note:Expected frequency indicates the frequency of shared neoantigens predicted by recurrent mutations in combination with highly frequent HLA alleles.Observed frequency，the frequency of shared neoantigens in 7748 tumor samples.

To further understand the distribution of neoantigens at gene level，users can retrieve neoantigens by feeding in a gene name in the‘Browse’page（Figure 1E）.The retrieval results provide more functions than that indicated in each tumor type，such as sorting and searching within results，making it easier to search the most frequent neoantigens generated by each gene.For instance，the potential neoantigen based on BRAF V600E mutation and HLA-A03:01 exists in 117 tumor samples，and corresponding neoantigens based on several mutations of KRAS and PIK3CA are also shared in more than 40 tumor samples（Table 1）.