《Table 1Top 10 shared neoantigens of 7748 tumor samples from TCGA》
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《TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis》
Note:WT,wild type;MT,mutant.Amino acid residue changes caused by somatic mutations are indicated in red.
To further understand the distribution of neoantigens at gene level,users can retrieve neoantigens by feeding in a gene name in the‘Browse’page(Figure 1E).The retrieval results provide more functions than that indicated in each tumor type,such as sorting and searching within results,making it easier to search the most frequent neoantigens generated by each gene.For instance,the potential neoantigen based on BRAF V600E mutation and HLA-A03:01 exists in 117 tumor samples,and corresponding neoantigens based on several mutations of KRAS and PIK3CA are also shared in more than 40 tumor samples(Table 1).
图表编号 | XD0021323500 严禁用于非法目的 |
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绘制时间 | 2018.08.01 |
作者 | Jingcheng Wu、Wenyi Zhao、Binbin Zhou、Zhixi Su、Xun Gu、Zhan Zhou、Shuqing Chen |
绘制单位 | Institute of Drug Metabolism and Pharmaceutical Analysis and Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University、Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Scie |
更多格式 | 高清、无水印(增值服务) |