《Table 2–The preparation and characteristics of novel carrier-free based nano-drug delivery systems

《Table 2–The preparation and characteristics of novel carrier-free based nano-drug delivery systems   提示：宽带有限、当前游客访问压缩模式
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《Evolution from small molecule to nano-drug delivery systems:An emerging approach for cancer therapy of ursolic acid》


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Mesoporous silica nanoparticles（MSNs）is a promising drug delivery system due to its high surface area，narrow pore size distribution，superior chemical property，mechanical stability，and facile surface functionalization[79–83].UA-loaded MSNs（UA@MSN-UA） with particle size of 100 nm displayed a higher cytotoxic effect against Hep G2 cells than free UA[66].The nanoparticles released 76%of the loaded UA in 96 h at p H 5.5，whereas 53%was released at p H 7.4，indicating its sustained and p H-responsive release properties.In another study，our group developed active targeting ligand FA and chitosan comodified UA-loaded MSNs（UA@M-CS-FA）and evaluated the targeted delivery efficiency of UA to FA-receptor positive cancer cells[67].Mechanistically，UA@M-CS-FA exhibited remarkable inhibition on the migration of cancer cells through regulating P53/MMP-9/PTEN/CD44 proteins.Also，in vivo experiments revealed that UA@M-CS-FA significantly inhibited the tumor proliferation and migration[67].Similarly，another mesoporous silica nanocarrier（MSN-CS-LA）modified with p H-responsive chitosan and LA was developed for codelivering UA and sorafenib.This nanoparticle could improve the cellular uptake and internalization of drugs against ASGPR over-expressing cell lines[68].In conclusion，the development of multifunctional MSNs provides a new way for efficiently delivering UA into tumor tissues.

图表编号XD00182756300    严禁用于非法目的
绘制时间2020.12.01
作者Jingwei Shao、Yifan Fang、Ruirui Zhao、Fangmin Chen、Mingyue Yang、Jiali Jiang、Zixuan Chen、Xiaotian Yuan、Lee Jia
绘制单位Cancer Metastasis Alert and Prevention Center, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University、Marine Drug R&D Center, Institute of Oceanography, Minjiang University、Cance
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