《Table 1 Subcutaneous specific immunotherapy protocol》

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《Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma》

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A total of 37 children aged 6–18 years were enrolled through the Department of Pediatrics at Chia-Yi Christian Hospital.The study assessed 13 allergic asthmatic children who received Der p SIT（SIT），12 non-SIT allergic asthmatic（AA）controls，and 12 healthy controls（HC）.The children in the SIT group that received Der p SIT therapy，according to the protocol recommended by the manufacturer（Table 1），were consecutively followed up in our outpatient clinic for 3 years.Further details on the methods are provided in Supplementary Information Section.