《Table 3 Binding affinity of modified P40–48 peptides to HLA-A*0201 molecules》

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《A modified HLA-A~*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses》

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Residues in bold represent modifications from the native sequence.Abbreviations:FI，fluorescence index；MFI，mean fluorescence intensity.aPeptide binding was evaluated by the MFI.bData are presented as the mean±s.e.m.of six independent experiments.

The immunogenicity of MHC class I-restricted peptides requires the capacity to bind and stabilize MHC class I molecules on the cell surface.Therefore，we next sought to measure directly the interaction strength between the peptides and HLA-A2.1 using a conventional binding and stabilization assay with T2 cells.Of the 17 peptide analogs，16（except 7H）had stronger affinity than the native peptide P40–48（Table 3）.