《Table 2 HLA-A*0201 native peptides and synthetic analogs》
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《A modified HLA-A~*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses》
Modifications from the native sequence are indicated in bold.Abbreviation:hPEBP4，human phosphatidylethanolamine-binding protein 4.aPropred-I prediction software available at http://crdd.osdd.net/raghava//propred1/.bNative peptide derived from hPEBP4.
The immunogenicity of MHC class I-restricted peptides requires the capacity to bind and stabilize MHC class I molecules on the cell surface.Therefore，we next sought to measure directly the interaction strength between the peptides and HLA-A2.1 using a conventional binding and stabilization assay with T2 cells.Of the 17 peptide analogs，16（except 7H）had stronger affinity than the native peptide P40–48（Table 3）.
| 图表编号 | XD0010736200 严禁用于非法目的 |
|---|---|
| 绘制时间 | 2018.08.01 |
| 作者 | Weihong Sun、Junyi Shi、Jian Wu、Junchu Zhang、Huabiao Chen、Yuanyuan Li、Shuxun Liu、Yanfeng Wu、Zhigang Tian、Xuetao Cao、Nan Li |
| 绘制单位 | National Key Laboratory of Medical Immunology and Institute of Immunology,Second Military Medical University、Institute of Immunology,Zhejiang University School of Medicine、Biotherapy Center,The Affiliated Central Hospital of Qingdao University、Department |
| 更多格式 | 高清、无水印（增值服务） |
