《Table 1A comparison of the conventional drug discovery and development process with those of the CA

《Table 1A comparison of the conventional drug discovery and development process with those of the CA   提示：宽带有限、当前游客访问压缩模式
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《从药物开发的角度看工程化T细胞疗法》


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CD19 is ubiquitously expressed on all stages of B cells except for hematopoietic stem cells（HSCs）and certain plasma cells.It is also expressed on most B lineage leukemia and lymphoma cells[51，55].It is expected that a successful adoptive CART19 transfer will eliminate B lineage malignancies and normal B cells leading to B cell aplasia.As the treatment does not eradicate the vital HSC，and as B cell aplasia is treatable with intravenous immunoglobulin replacement，CD19 is an excellent target for eliminating B lineage malignancies via the adoptive transfer of CAR T cells due to its antibody accessibility，tumor specificity，and non-lethal normal organ tissue distribution[46，56].

图表编号XD0061017800    严禁用于非法目的
绘制时间2019.02.01
作者Fang Chen、Joseph A.Fraietta、Carl H.June、许中伟、J.Joseph Melenhorst、Simon F.Lacey
绘制单位Department of Pathology and Laboratory Medicine,University of Pennsylvania、Center for Cellular Immunotherapies,University of Pennsylvania、Department of Pathology and Laboratory Medicine,University of Pennsylvania、Center for Cellular Immunotherapies,Univer
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