《Table 4–The parameters of conventional and sustained tablets in Beagle dogs (Mean±SD, n=6) .》

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《"Succinylated whey protein isolate as a sustained-release excipient of puerarin derivative oral tablets:Preparation,optimization and pharmacokinetics"》

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The main pharmacokinetic parameters for conventional or sustained release tablet of PR-5 in beagle dogs after oral administration and the absolute bioavailability of PR-5 were summarized in Table 4 and the drug concentration-time curve was shown in the Fig.7.The plasma concentration from the conventional tablets increased quickly and reached the maximum concentration within 1 h，and the drug was more quickly eliminated.PR-5 sustained release protein tablets maintained drug concentration in plasma up to 18 h as compared to the conventional formulation，where the drug levels could no longer be detected after 12 h.It was also observed that MRT of PR-5 sustained release protein tablets（5.90±0.795 h）was1.2-times higher than that of the conventional formulation（4.626±0.866 h），indicating prolonged residence in the body.In contrast，the Tmax values for the sustained release protein tablets was approximately 1.58 fold greater than those of the conventional tablets as further evidenced by the significantly prolonged T 1/2.Thus，significant sustained drug-plasma levels were observed with rate-sustained release of PR-5 from the S-WPIs tablets after oral administration when compared to the conventional formulation.