《Table 7–Friability test of formulations with different amounts of binder (to confirm capping-like b

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《Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures》

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It is important to design tablet formulations so as to avoid potential manufacturing failures.Previously，we assessed our evaluation method in the design of formulations prepared by direct compression.Here，we assessed it in the design of formulations prepared by wet granulation.We optimized the amounts of binder，disintegrant，and lubricant and prepared samples by fluid bed granulation，and evaluated the“Tableting properties”of the samples using the GTP-1.Tableting failures（capping and binding in particular）occurred when samples that the GTP-1 had evaluated as having poor“Compactability”or“Manufacturability”were compressed on an actual rotary tableting machine.In particular，the tablets were at risk of capping when TFS measured by the GTP-1 was?1.5 MPa，and of binding when ejection stress was?20 MPa.Thus，problems predicted by the GTP-1 were confirmed in actual tableting.We would therefore be able to design tablet formulations that avoid tableting failures at the commercial scale by optimizing the composition through evaluation on the GTP-1.We would also be able to scale up production on the same basis.