《Table 4–“Tableting properties”of formulations with different amounts of lubricant, evaluated using

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《Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures》

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We have previously shown that it is advisable to design formulations to optimize both“Compactability”and“Manufacturability”，but the results of Samples 1，6，and 7 showed high ejection stress（≥5 MPa），and the points were plotted in range（III），indicating poor“Manufacturability”.Insufficient Mg St causes tableting failures such as sticking and binding[16].To improve“Manufacturability”，we added different amounts of MgSt to Sample 1-based formulations.Each tablet contained0.6 mg Mg St in Sample 8，1.2 mg Mg St in Sample 1，2.4 mg Mg St in Sample 9，and 3.2 mg Mg St in Sample 10.The ejection stress decreased as the amount of lubricant increased（Table 4；Fig.4）.That of Sample 8 was extremely high，and the sides of the tablets were deeply damaged during ejection.For this reason，TFS of Sample 8 was low.Samples 9（2.4 mg Mg St）and 10（3.6 mg Mg St）were plotted in range（I），indicating good“Compactability”and“Manufacturability”（Table 4；Fig.4）.