《Table 2–“Tableting properties”of formulations with different amounts of disintegrant, evaluated usi
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《Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures》
We examined the effect of binder on TFS in formulations with14.4 mg of disintegrant per tablet.Each tablet contained PVP at 4 mg in Sample 4,8 mg in Sample 5,12 mg in Sample 1,18 mg in Sample 6,or 24 mg in Sample 7(Table 1).TFS was<2 MPa in Samples 4 and 5,and the points were plotted in range(IV),indicating poor“Compactability”(Table 3;Fig.3).Therefore,≥12 mg of binder is needed to give sufficient hardness(Table 3;Fig.3).
图表编号 | XD00594000 严禁用于非法目的 |
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绘制时间 | 2018.03.01 |
作者 | Takashi Osamura、Yoshiko Takeuchi、Risako Onodera、Masahiro Kitamura、Yoshiteru Takahashi、Kohei Tahara、Hirofumi Takeuchi |
绘制单位 | Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University、Pharmaceutical Technology Department, Sawai Pharmaceutical Co.Ltd、Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University、Laboratory of Pharmaceutical Engineering, G |
更多格式 | 高清、无水印(增值服务) |