《Table 6–Friability test of formulations with different amounts of disintegrant (to confirm capping-

  提示：宽带有限、当前游客访问压缩模式

本系列图表出处文件名：随高清版一同展现

《Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures》

1. 获取 高清版本忘记账户？点击这里登录

1. 下载图表忘记账户？点击这里登录

Samples 2（28.8 mg CPD）and 3（43.2 mg CPD）showed poor“Compactability”in Section 3.1.On the rotary tableting machine，sample 1（14.4 mg CPD）reached the target tablet thickness（4.40 mm）when compressed at 11 k N（Table 5）.However，Sample2 exceeded the target thickness at 4.47 mm.To reduce the thickness to 4.40 mm，we had to increase the pressure to 16 kN.Sample 3 exceeded the target thickness even more at 4.54 mm，and was still 4.50 mm thick at 20 kN.All three samples disintegrated within the target of 7 min.All also reached the target hardness of 60 N，but Samples 2 and 3 tended to crack in capping layers（laminar separation）during hardness testing（Fig.5 （A）） .Tablets that crack in this way during transportation will split，potentially leading to capping.For this reason，we tested the friability of these samples（Table 6）.Sample 1did not crack in capping layers even after 3000 rotations.Sample2 tablets compressed to 4.47 mm did not crack even after 3000rotations，but among the tablets reduced to 4.40 mm，2 tablets cracked after 2000 rotations and 4 cracked after 3000 rotations.Furthermore，among the tablets of Sample 3，10 tablets 4.54 mm thick and all 20 tablets 4.50 mm thick cracked.Thus，Samples2 and 3（TFS≤2 MPa by GTP-1）were likely to experience capping-like breakage when made on a rotary tableting machine.Tablets with>14.4 mg of disintegrant were at high risk of capping failure.Therefore，the appropriate amount of disintegrant per tablet was 14.4 mg.The poor predicted“Compactability”of Samples 2 and 3 was reflected in the actual tableting results.