《Table 1 Short term randomized control trial investigating the effects of continuous positive airway

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《Treatment of central sleep apnea in patients with heart failure: Now and future》

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RCT:Randomized control trial；CPAP:Continuous positive airway pressure；HF:Heart failure；CSA:Central sleep apnea；LVEF:Left ventricular ejection fraction；NYHA:New York Heart Association；NE:Norepinephrine；MIP:Maximal inspiratory pressure；ANP:Atrial natriureti

In the 1990s and early 2000s，various small-scale randomized control studies identified an effect of the CSA treatment by CPAP on cardiovascular endpoints in patients with HF.In addition，several short-term（0-3 mo）studies reported that CSA treatment by CPAP caused a relative increase（30%）in the left ventricular ejection fraction（LVEF），a reduction in the mitral regurgitation，a decrease in both the overnight urinary norepinephrine（NE）excretion and the daytime NE concentration and an improved quality of life in patients with HF（Table 1）[7-9].