《Table 1 Recombinant human insulin concentration (pg/mg tissue) in different brain regions over a 6-

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《Rapid transport of insulin to the brain following intranasal administration in rats》

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Data represent mean±SEM from five rats in each group.*P<0.05，vs.0 minute（one-way analysis of variance followed by Bonferroni post hoc analysis）.OB:Olfactory bulb；SN:subtantia nigra；VTA:ventral tegmental area.

The specificity of the ELISA kit for rh-Ins was first validated based on positive controls of human insulin and rat samples from the control group.The calculated concentration of two positive controls in each ELISA consistently reached within 5%range of predicted values.The concentration of rhIns from PBS-treated control rats were all below detectable limit，therefore they were assigned a value of 0.As shown in Table 1，significant amounts of rh-Ins were detected in all brain regions except the cerebral cortex in rh-Ins-treated rats.Rh-Ins reached the peak value at 15 minutes and declined substantially overtime，but remained significantly higher than baseline levels in most regions at 6 hours.Neither the dorsal or ventral division of the cortex showed a significant increase over baseline at any time points.