《Table 2 Selected glioma susceptibility genes and SNPs observed in at least 2 candidate association

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《脑肿瘤遗传流行病学及危险因素研究进展（英文）》

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The majority of the candidate gene-association studies[27-29]for glioma susceptibility have focused largely on 4 key pathways:DNA repair（particularly，doublestrand break repair），cell cycle，inflammation（allergies and infections），and metabolism.An updated collection of these studies is available at the Genetic Association Database online（http://geneticassociationdb.nih.gov/）.Although somewhat interesting results have been reported，many of these candidate gene studies are either preliminary or controversial.Only a few genes and single nucleotide polymorphisms（SNPs）have been consistently associated with glioma:DNA repair genes PRKDC（protein kinase，DNA-activated，catalytic polypeptide）p.G6721T，XRCC1（X-ray repair cross complementing 1）p.W399R，PARP1（poly ADP-ribose polymerase 1）p.A762V，MGMT（O6-methylguanine-DNA methyltransferase）p.F84L，ERCC1（excision repair cross-complementing 1，endonuclease non-catalytic subunit）p.A8092C，and ERCC2（excision repair cross-complementing 2，TFIIH core complex helicase subunit）p.Q751K；cell cycle gene EGF（epidermal growth factor）+61 A/G；and inflammation gene IL13（interleukin 13）p.R110G（Table 2）.