《Table 1 Molecular markers in different levels of glioma[9]》

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《影像组学在胶质瘤临床研究中的应用进展（英文）》

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IDH:Isocitrate dehydrogenase；TP53:Tumor protein p53；ATRX:Alpha-thalassemia/mental retardation syndrome X-linked；MGMT:O6-methylguanine-DNA methyltransferase

To date，World Health Organization Classification Update of the CNS Tumors 2016 is the first tumor classification based on both the molecular markers and histolog y[9-10].In this update，main molecular markers of gliomas（Table 1）were highlighted as I D H，1 p 1 9 q d el e t i o n，M G M T，T E RT，AT R X，an d p53[9-10].Those molecular changes were obser ved in various signaling pathways which participant the regulation of tumor behavior.After 9-year research from the CNS Tumors 2007，IDH1/2 still keep the title of“star molecule”in glioma.