《Table 1 Differentially expressed mi RNAs and target genes》

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《Differentially expressed miRNAs in premature infants with retinopathy-a bioinformatics analysis》

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Data Source The data in our study came from the study of Wang et al[9]and Zhao et al[10].Wang et al[9]analyzed the mi RNA profile data of retinal tissue between 40 C57BL/6neonatal mice with ROP and 40 without ROP（controls）on postnatal day 17.Finally，67 differentially expressed mi RNAs were identified.Zhao et al[10]compared mi RNAs in neonatal Sprague-Dawley rats.They found 66 differentially expressed plasma mi RNAs by deep sequencing technology on postnatal day 14.Based on the above data，we perform a stricter screening standard which is the significant mi RNAs are selected from the intersection of the above two articles（Wang et al[9]and Zhao et al[10]）.And fold change must fulfill greater than two in both studies.In addition，mi RNA sequence must be well conservative between human and rodent.After screening，only 1 up-regulated and 1 down-regulated mi RNAs passed the test，and were further selected into this study（Table 1）.Based on these findings，we try to identify the roles of mi RNA in ROP.