《Table 1 Top-20 KEGG terms of upregulated differentially expressed genes with the same variation ten

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《Bioinformatics analyses of differentially expressed genes associated with spinal cord injury:a microarray-based analysis in a mouse model》

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P<0.05，sorted by fold enrichment scores.KEGG:Kyoto Encyclopedia of Genes and Genomes；TNF:tumor necrosis factor；STAT:signal transducer and activator of transcription.

The gene expression dataset，GSE5296，was used to identify DEGs from a SCI murine model using a microarray representing approximately 34，000 genes.By comparing the control group and SCI subgroups at each time point，several DEGs were identified，with the numbers shown in Figure1.SCI led to upregulation of 2，460 genes in injured spinal cord at 7 days after injury，109 of which were upregulated at each time point.Moreover，many of these upregulated genes were associated with inflammation.In total，2010 genes were downregulated at the injury site at 7 days following SCI，30 of which were downregulated at each time point.Interestingly，the number of downregulated genes was always smaller than the number of upregulated genes at each time point.Overall，we identified 109 upregulated genes and 30downregulated genes with consistent directions of variation at each time point（Figure 2）.Additional Table 1 contains the complete list of DEGs.