《Table 1 A panel of mi RNAs controls the expression of the immune checkpoints》

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《Key questions about the checkpoint blockade-are microRNAs an answer》

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PD-L1:programmed death-ligand 1；TIM-3:T-cell immunoglobulin and mucin-domain containing-3；LAG-3:Lymphocyte-activation gene3；MPM:malignant pleural mesothelioma；CTLA-4:cytotoxic T-lymphocyte-associated protein 4；CRC:colorectal cancer；PD-1:programmed cell de

Mi RNAs fine tune the expression of immune checkpoint receptors and their ligands.One mi RNA can target several checkpoint molecules，mimicking the therapeutic effect of a combined ICB22.It is crucial to understand which are the hubs of the mi RNA regulatory network（Figure 1）in order to design therapies that target these super-connected nodes24.On the other hand，the immune checkpoint molecules can control the expression of mi RNAs，making the network robust and complex.A list of the mi RNAs that target the immune checkpoints and of the immune checkpoints that control the expression of mi RNAs can be found in Table 1.