《Table 1.Histomorphometry values from L3 vertebrae of wild-type (Lgals3+/+) , heterozygous (Lgals3KO

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《Enhanced cortical bone expansion in Lgals3-deficient mice during aging》

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OV，osteoid volume；BV，bone volume；BS，bone surface；OS，osteoid surface；O.Wi，osteoid width；N.Ob，number of osteoblasts；N.Oc，number of osteoclasts；Oc.S，osteoclast surface；MS，mineralizing surface；MAR，mineral apposition rate；Aj.AR，osteoid adjusted appos

To determine if increased cortical bone expansion could also contribute to the increased B.Ar observed in 36-wk Lgals3-deficient animals，we measured changes in cortical bone parameters byμCT.These results are shown in Supplementary Table 5.We observed a significant increase in total area（T.Ar）of both male and female Lgals3KO/KOfemurs（Fig.3d，g）starting at36 wk（+6.5%and+10.7%，respectively）.Lgals3KO/KOfemales also had significantly increased T.Ar at 48 wk（+8.8%）.Male Lgals3KO/+mice also had significantly increased T.Ar at 36 wk（+8.8%）.In addition，B.Ar was increased at 36 wk which was significant in Lgals3KO/KOfemales（+9.9%），but failed to reach significance in Lgals3KO/KOmales（Fig.3e，h）.The smaller cortical bone mass effect observed in Lgals3-deficient males may be related to a skeletal growth deficit in young Lgals3KO/+（T.Ar；-5.1%and B.Ar；-4.0%）and Lgals3KO/KO（T.Ar；-7.9%and B.Ar；-8.1%）mice at 12 wk（Fig.3g，h），although these results did not reach statistical significance.Young female Lgals3-deficient mice had mostly normal or slightly elevated cortical bone parameters at 12 wk，which suggested that galectin-3 may play a role in male bone mass accrual during early development.