《Table 1 Polymerization results of H-shaped polymer and its precursors》

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《Controlled Self-assembly of Thermo-responsive Amphiphilic H-shaped Polymer for Adjustable Drug Release》

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a Calculated by the integration of corresponding protons in 1H-NMR spectroscopy；b Calculated by（Wproduct-Winitiator）/Wmonomer×100%；c Calculated by Wproduct/（Winitiator+Wmonomer）；d Calculated by（[monomer]/[initiator]）×（Conv.）×Mn（monomer）+Mn (in

In the 1H-NMR spectrum of PNIPAM-（PTHF）-PEG-（PTHF）-PNIPAM（Fig.1C），the characteristic signals from the PTHF chains（Fig.1A）appeared at 3.41 and 1.62 ppm in comparison with that of PNIPAM-（N3）-PEG-（N3）-PNIPAM（Fig.1B）.The molar ratio of the ethylene oxide units in the PEG block to the tetramethylene ether units in the PTHF block and the NIPAM units in the PNIPAM block was close to 45:86:180，as calculated by 1H-NMR integral analysis.This integral ratio indicated that one PNIPAM-（N3）-PEG-（N3）-PNIPAM chain was covalently linked to two PTHF-Alk chains.In the FTIR spectrum of PNIPAM-（PTHF）-PEG-（PTHF）-PNIPAM（Fig.2c），no characteristic bands of azido groups were observed near 2100 cm-1，indicative of the successful click reaction.The excess PTHF-Alk was reacted with Merrifield-N3 resin and removed by filtration.Additionally，the SEC/MALLS curve of the H-shaped polymer was monomodal，and the elution peak appeared at the higher molecular weight side，unlike the peaks of the two building blocks（Fig.3）.The Mn，SEC of H-shaped polymer was 3.24×104 g/mol，in accordance with the value calculated by 1H-NMR.In addition，the corresponding Mw/Mn value was as narrow as 1.11.These results demonstrated that an H-shaped polymer with one PEG chains，two PTHF chains and two PNIPAM chains as building blocks was successfully prepared.The structural parameters of all the polymers obtained in this work are summarized in Table 1.