《Table 2 Results of specificity, linearity and LOQ for MAC and its associated impurities》

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《指示稳定性的高效液相色谱方法和强制降解研究片剂型马西替坦中的杂质（英文）》

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RT:retentio n tim e；RRT:relative retentio n tim e，RT o f im purity peak/RT o f MAC peak；C:m ass co ncentratio ns w ith respect to 5μg/m L limit level，2.2%（LOQ）-215%for Impurity 3，2.1%（LOQ）-209%for Impurity 1，2.6%（LOQ）-264%for Impurity 2，2.5% (L

LOQ is the m inim um am o unt o f analyte that can be quantitatively determ ined w ith precisio n and accuracy using the develo ped m etho d.This can be determ ined by m easuring the signal to no ise（S/N）ratio（w hich sho uld be>10）o f different drug co ncentratio ns and im purity standard so lutio ns.The m inim um co ncentratio ns that can be detected w ith precisio n fo r MAC and its im purities w as established at appro x im ately 0.01%o f 1 000μg/m L w ith an S/N ratio o f≥10 as sho w n in Table 2.