《Table 2–Effects of BJOE on pepsin activity and total acidity in rats with gastric lesions induced b

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《Activity of Brucea javanica oil emulsion against gastric ulcers in rodents》

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Gastric ulcer model prepared with pylorus ligation is also used in rat mostly and it is generally used to investigate the effect of tested drugs on gastric secretions.The ligation of the pyloric end of stomach causes the accumulation of gastric secretion，enhances the secretion of pepsin which leads to the auto-digestion of gastric mucosa，breaks down the gastric mucosal barrier and finally results in gastric wall injury[45，46].Pretreatment with BJOE（0.5 ml/kg and 1.0 ml/kg）and cimetidine showed protective effect on the gastric ulcer.The protection percentage of the high dose of BJOE was 63.5%（P<0.01，Fig.8）.The results of total acidity presented in Table 2 confirmed the data，which clearly showed the inhibitory effects of the drug on gastric acid.The inhibitory rate of BJOE（1.0 ml/kg）was 33.9%（P<0.05，Table 2）.However，there were no obvious changes in the pepsin activity among all the groups（P>0.05，Table 2）.Data from histopathological examination showed that the mucosa epithelium of gastric tissues in the rats with the ulcer desquamated and inflammatory cell infiltration was observed（Fig.9A）.Pretreatment with 1.0 ml/kg of BJOE had a certain protection effect on the lesions and mucosa epithelium looked almost normal（Fig.9C）.The effect of 0.5 ml/kg of BJOE was not obvious as that of 1.0 ml/kg for some disruption of the mucosa also could be seen in Fig.9B.The possible mechanism of the anti-ulcer action of BJOE may be relevant to the characteristics of the drug.When it is given before the ligation surgery，it may be absorbed into the bloodstream to be in a ready status for regulating the intrinsic factors ahead of the occurrence of gastric ulcer.In addition，the advantage of BJO emulsion，when it is orally applied in the therapy of gastric ulcer，is that a colloidal protective layer can be formed in advance which covers the inner surface of stomach to resist aggressive factors produced after the stimulation of pylorus ligation.The data about pepsin activity，however，did not show any significant effect.It might be suggested that the suppressive effect of BJOE on the gastric ulcer mainly come from its strengthening of the protective facet such as gastric mucus secreted rather than decreasing of the erosive facet like pepsin.