《Table 3 Effects of VCFP on MDA content and SOD, CAT and GSH-Px activity in mice with acute alcoholi

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《Study on Protection Mechanism of Viscum coloratum (Kom.) Nakai f. lutescens kitag Fruit Polysaccharides on Mice with Acute Alcoholic Liver Injury》

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Compared with the control group，*P<0.05，**P<0.01；compared with the model group，#P<0.05，##P<0.01.

MDA is a product of lipid peroxidation due to the attack of organisms by oxygen radical to organism，and the determination of its content could reflect the degree of lipid peroxidation in organisms.CAT exists in various tissues of animals，especially in liver at a high level，and serves as a kind of enzyme catalyzing the decomposition of H2O2into oxygen and water.SOD is a free-radical scavenger，which widely exists in various tissues of living body，and could scavenge superoxide anion free radical，reduce cytotoxicity，and weaken lipid peroxidation and cytomembrane injury，as well as reducing reduce the inflammation caused by excessive free radical.GSH-Px is a kind of important lytic enzyme of peroxides widely existing in organisms，which could reduce toxic peroxides to non-toxic hydroxyl compounds，and promote the decomposition of H2O2simultaneously，thereby protecting the structure and function of cytomembrane from interference and damage by peroxides.Therefore，CAT，SOD and GSH-Px are important antioxidant enzymes in living body[22]，as well as important free-radical scavengers existing in the antioxidant system in cytoplasm.The effects of VCFP on MDA content and SOD，CAT and GSH-Px activity in mice with acute alcoholic liver injury are shown in Table 3.Compared with the control group，the model group had very significantly increased MDA content and CAT and GSH-Px activity（P<0.01），and very significantly decreased SOD activity（P<0.01），which might be due to that after modeling，the mouse liver was injured，MDA，CAT and GSH-Px were more sensitive to external environment and increased remarkably，and the production system of SOD was destructed to a certain degree，resulting in reduced SOD.After 28 d of treatment，compared with the model group，the low-dose VCFP group had very significantly decreased MDA content（P<0.01），significantly decreased GSH-Px activity（P<0.05），significantly increased SOD activity（P<0.05），and decreased CAT activity without a significant difference（P>0.05）.The medium-dose VCFP group showed very significantly decreased MDA content（P<0.01），significantly decreased CAT and GSH-Px activity（P<0.05），and SOD activity significantly increased（P<0.05）.The high-dose VCFP group exhibited very significantly decreased CAT and GSH-Px activity（P<0.01），significantly increased MDA content，and significantly decreased SOD activity（P<0.05）.After 28 d of treatment，compared with the control group，the low-dose VCFP group showed very significantly increased MDA content and CAT activity（P<0.01），and significantly increased SOD and GSH-Px activity（P<0.05）.The medium-dose VCFP group exhibited very significantly increased MDA content（P<0.01），significantly increased CAT and GSH-Px activity（P<0.05），and decreased SOD activity without a significant difference（P>0.05）.The MDA content and CAT，SOD and GSH-Px activity in the high-dose VCFP group exhibited no significant differences from the control group（P>0.05）.It could be seen that after the treatment with VCFP at different doses，the production system of SOD enzyme in mouse was well recovered，and the MDA content and CAT and GSH-Px activity were also effectively regulated and reduced.It indicates that VCFP could well protect the liver tissue of mice with acute alcoholic liver injury，and is of great significance to the maintaining of redox equilibrium in mice.