《Table 6–Effects of Intra tracheal instillations of DPI formulation on BLM induced changes in total
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《Pulmonary delivery of liposomal dry powder inhaler formulation for effective treatment of idiopathic pulmonary fibrosis》
Values are expressed as the mean±SD；n=12 rats；*P<0.05，**P<0.01，***P<0.001，compared with the corresponding control group values；ns–non-significant，#P<0.05，##P<0.01 plain drug treated animals compared with the bleomycin treated group values after 14 d
Lung tissue samples in the Control Group had a normal pulmonary architecture with thin-lined alveolar septa，normal cellularity and only a few alveolar macrophages，while the samples in Group BLM had typical fibrotic changes including infiltration with excessive inflammatory cells large collagen depositions，large fibrous areas and collapsed alveolar spaces were found in the samples viewed under a light microscope.（Fig.5 A，B）After treatment with prepared plain drug and DPI formulations on bleomycin-induced fibrotic rats；DPI formulation had shown the decrease in a number of inflammatory cells and the thickness of the alveolar septa.（Fig.5 C，D，E，F）.To confirm the effects of prepared plain drug and DPI formulations on the histopathology of BLM-induced lung injury and fibrosis，the overall grades（Table 7）of inflammatory and fibrotic changes in the lungs were estimated by numerical scoring.The scores of alveolitis and fibrosis in the lung sections of BLM+DPI formulation group was significantly decreased，compared with those of the BLM+Plain drug formulation.DPI formulation containing BUD and COL significantly prevented the developments of lung fibrosis produced by bleomycin，confirmed by the pathologic investigation，measurements of lung hydroxyproline content，Myeloperoxidase activity and BALF analysis.No significant differences were found in all parameters for optimized formulation（M2）at both room condition（25°C±2°C，60%±5 RH）and at refrigerated conditions（2-8°C）up to six months.
| 图表编号 | XD00186256600 严禁用于非法目的 |
|---|---|
| 绘制时间 | 2018.01.01 |
| 作者 | S.Chennakesavulu、A.Mishra、A.Sudheer、C.Sowmya、C.Suryaprakash Reddy、E.Bhargav |
| 绘制单位 | Pharmacy Department, NDDS Laboratory, Donors Plaza, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda、Pharmacy Department, NDDS Laboratory, Donors Plaza, Faculty of Technology and Engineering, The Maharaja Sayajirao Univer |
| 更多格式 | 高清、无水印（增值服务） |
