《Table 1 miRNAs with significantly altered expression in retinas of mice with OIR identified by micr

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《Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy》

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Data were filtered by fold change 1.5-fold up and down，and P<0.05.

Altered miRNA Expression in Mice with Oxygen-induced Retinopathy To investigate the difference in retinal miRNAs expression profile between OIR and control mice，we performed the Exiqon microarray with retinas from 6 mice（3 OIRs and 3 controls）.miRNAs microarray data analysis suggested that 289 miRNAs were upregulated in OIRs compared to controls with fold change greater than 1.5-fold，and 59 miRNAs were downregulated at more than 1.5-fold（Figure 1A）.As showed in Figure 1 and Table 1，among these miRNAs，3 miRNAs（mmu-miR-350-3p，mmu-miR-202-3p，and mmu-miR-100-5p）were significantly upregulated，and8 miRNAs（mmu-miR-711，mmu-miR-10a-3p，mmu-miR-201-3p，mmu-miR-383-5p，mmu-let-7c-5p，mmu-let-7e-5p，mmu-miR-30c-1-3p，and mmu-miR-882）were significantly downregulated in mice with OIR.The heatmap revealed distinguishable miRNA expression profile between control and experimental group except for OIR1（Figure 1B），which may be caused by individual difference.In order to avoid experimental errors，another group of OIR and control mice were used for validation of altered miRNA expression by qRT-PCR.