《Table 2B The significant enriched analysis of down-regulated DEGs in glaucoma with ocular hypertens

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《基于生物信息学整合分析探讨青光眼高压反应性视神经星形胶质细胞相关核心基因（英文）》

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Note:*P<0.05 as the cut-off criterion.

Candidate DEGs functions and pathways enrichment were analyzed using multiple online databases，including DAVID and KEGG PATHWAY.GO function enrichment was analyzed by DAVID online tool，and the DEGs functions were classified into three groups as follows:BP，CC and MF（Table 2A and 2B，Figure 2）.As shown in figure 2 and table 2A and 2B，in the BP group，up-regulated genes mainly enriched in humoral immune response，regulation of NMDA receptor，cellular response to stress，chloride transport，regulationofsynapticplasticity，gamma-aminobutyric acid signaling pathway，retina homeostasis and learning or memory，and the down-regulated genes mainly enriched in regulation of prostatic bud formation complement activation，regulation of cartilage development，type B pancreatic cell development，regulation of chondrocyte differentiation，regulation of endothelial cell migration，ureteric bud morphogenesis，regulation of protein kinase C activity，regulation of MAPK cascade，SMAD protein signal transduction and regulation of apoptotic process.In the CC group，up-regulated genes mainly enriched in cell junction，extracellular region，extracellular space，extracellular exosome，GABA-A receptor complex，Post synapse and dendrite，and the down-regulated genes mainly enriched in extracellular region，extracellular space and blood microparticle.In the MF group，up-regulatedgenesmainlyenrichedin extracellular-glutamate-gated ion channel activity，and the down-regulated genes mainly enriched in BMP receptor binding，ephrin receptor binding and phosphodiesterase activity.