《Table 3 Comparison of serological response in azithromycin-or BPG-treated early syphilis patients a

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《Relationship between the high frequency of 23S rRNA point mutations in Treponema pallidum and low serological response rate to azithromycin treatment in China》

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Chi-square tests were conducted，and P-values of<0.05 were considered to indicate statistical significance.Positive，patients who presented as A2058G-or A2059G-positive；Negative，patients who presented as A2058G-and A2059G-negative；RPR，rapid plasma regain

The factors associated with serological response at12-months follow-up are shown in Table 4.Both in univariate and multivariate analyses，patients with higher RPR titers（RPR，≥1∶64）were more likely toachieve serological response than those with lower RPR titers（RPR，≤1∶8；OR，0.23；95%CI，0.09-0.37）.Patients in the azithromycin group were less likely to achieve serological response than those in the BPG group（OR，121.50；95%CI，35.38-386.17）.Additionally，subgroup analyses showed that there was no significant relationship between the serological response and the following demographic and clinical characteristics，including gender distribution，age，number of sexual partners，and syphilis stage.