《Table 2–Independent variables in two-level, three-factor experiment design for coating of PC tablet

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《Development and bioequivalence study of potassium chloride extended release tablets》

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Due to high solubility of PC in water，the ER tablets were designed in combination of matrix structure core and retard coating.Either stearyl alcohol or carnauba wax was used as retardant for the matrix.Tablets were prepared by direct compression process:PC was mixed with either stearyl alcohol or carnauba wax in a cubic mixer for 30 min.The mixture then was heated in an oven for 1 h at 100 o C and passed through1 mm sieve.The lubricant was added to the granules and the final mixture was mixed again for 5 min in a cubic mixer.The oblong-shaped tablets were compressed in the rotary tableting machine.The average weight of tablets was in the range of 630–655 mg depending on the compositions of the tablets as could be seen in Table 1.The hardness of the tablets was maintained in the range of 180–200 Newtons.