《Table 2–HPLC analysis of Cyclosporine A (CsA) in lipid digestion experiments in vitro.》

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《Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery》

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The compositions of all SNE formulations were shown in Supplementary Table S1.Each SNE is consisted of ethanol，1，2-propanediol，surfactant and oil phase（1:1:4:4，w/w）.Briefly，F127（25 mg）was firstly dissolved in the mixture of co-solvents（50 mg ethanol and 50 mg 1，2-propanediol）.（CsA or Di I was dissolved simultaneously at the first step for pharmacokinetic study and fluorescent detection experiments，respectively.）Then，cremophor EL（200 mg）was introduced and the mixture was added to the oil phase（200 mg，either SCT or LCT），followed by vibrating for 60 s at room temperature to make it homogeneity.Finally，formulations were dispersed in phosphate buffer saline（PBS）before use.