《Table 1 A summary of dysregulated epigenetic modifications in B cells in diseases》

《Table 1 A summary of dysregulated epigenetic modifications in B cells in diseases》   提示：宽带有限、当前游客访问压缩模式
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《Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity》


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Abbreviations:RA，rheumatoid arthritis；SLE，systemic lupus erythematosus.

In a recent epigenome-wide association study，406 365 Cp Gs in 52 MZ twin pairs discordant for T1D in CD4+T cells，CD19+B cells and monocytes were analyzed.A substantial enrichment of differentially variable Cp G positions was observed in these three different cell types from T1D twins，126suggesting the contribution of DNA methylation of B cells to T1D development.Although there is little evidence showing the association of epigenetic modifications in B cells with the pathogenesis of T1D，epigenetic drugs such as 5-Aza，127HDACs128，129and HDAC inhibitors130，131may exert their therapeutic effects on T1D via modifying B-cell activation and differentiation.Thus further studies on the potential link between abnormal epigenetic regulation of B cells and T1D may broaden our understanding of T1D pathogenesis（Table 1）.

图表编号XD0010734000    严禁用于非法目的
绘制时间2018.07.01
作者Haijing Wu、Yaxiong Deng、Yu Feng、Di Long、Kongyang Ma、Xiaohui Wang、Ming Zhao、Liwei Lu、Qianjin Lu
绘制单位Department of Dermatology,Second Xiangya Hospital,Central South University,Hunan Key Laboratory of Medical Epigenomics、Department of Dermatology,Second Xiangya Hospital,Central South University,Hunan Key Laboratory of Medical Epigenomics、Department of Der
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